Vol. 7, Issue 2, Part B (2025)

In this study, gentamicin (100 mg/kg BW/day i.p.) produces nephrotoxicity as evidenced by decrease in body weight, urine volume, elevate in kidney weight, blood urea, uric acid, serum creatinine, decrease creatinine clearance and renal tubular necrosis. The ethanolic and ethyl acetate extracts of Thespesia populnea at a dose of 400 mg/kg BW/day induced significant increase in urine volume, as compared to gentamicin treated group. Ethanolic extract (400 mg/kg BW/day p.o.) of Thespesia populnea (L) bark showed significant (p<0.001) decrease serum urea (UR), uric acid (UA) and creatinine (CR) level. The findings suggest that the extract of Thespesia populnea possesses marked Nephroprotective activity with minimal toxicity.