Vol. 6, Issue 1, Part A (2024)

Moringa oleifera Lam. is referred as “Miracle tree” in tropics and sub-tropics regions of world. Moringa oleifera Lam. is not a big size tree with approximately 4 to 8 m height. It is cultivated all over the world due to its multiple food & pharmaceutical utilities. Every part of Moringa is used for certain nutritional and/or medicinal purpose. Besides being a good source of protein, vitamins, oils, fatty acids, micro-macro minerals elements and various phenolics, it is also reported as anti-inflammatory, antimicrobial, antioxidant, anticancer, cardiovascular, Hepatoprotective, anti-ulcer, diuretic, antiurolithiatic and antihelmintic. This research is oriented to design nephroprotective effect of ethanolic extract of Moringa oleifera root in gentamicin induced experimental model. The ethanol extract of roots of Moringa oleifera (ERMO) selected for further studies in the present work. The Moringa oleifera phenolic compounds like flavonoids, saponins etc., are a major group of components that acts as primary antioxidant or free radical scavengers. The antioxidant activity of n-hexane, ethanol and aqueous extracts of the Moringa olieifera was measured by the scavenging activity of DPPH radical, hydroxyl radical (OH.), hydrogen peroxide radical and reactive oxygen species. The acute toxicity studies of moringa extracts were performed by up and down method (OECD 425). No mortality and morbidly were found up to 2000mg/kg body weight in ethanol extracts of Moringa oleifera.