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International Journal of Pharmacognosy and Clinical Research

Vol. 5, Issue 1, Part A (2023)

Synergistic effect of metformin combination with garlic on anti-diabetic activity: A review

Author(s):

Amol V Supekar, Bharat V Jadhav, Shital D Sole, Rutuja R Shinde, Akanksha B Sagade and Arti S Satbhai

Abstract:

Diabetes mellitus (DM) is a disorder in which patients have high blood sugar levels and is a major health concern all over the world. Recent advances in the pharmacology of diabetes mellitus have resulted in the identification of multiple therapeutic medication targets for effectively lowering glucose levels, with Metformin with garlic being the most successful of these. In the treatment of diabetes, anti-diabetic medications are employe. Metformin has become the most often prescribed glucose-lowering medication in the world. Metformin is a biguanide that decreases blood glucose concentration by mechanisms different from those of insulin secretagogues, such as sulphonylureas, or exogenous insulin therapy. Along with pharmacological treatment represented by oral hypoglycemic medications (For type 2), and non-pharmacological treatment, represented by exercise and diet; natural herbal extracts such as Garlic also showed an additional reduce in blood glucose level in these patients. Garlic contains diverse bioactive compounds, such as allicin, alliin, diallyl sulfide, diallyl disulfide, diallyl trisulfide, ajoene, and S-allyl-cysteine. Substantial studies have shown that garlic and its bioactive constituents exhibit antioxidant, anti-inflammatory, antibacterial, antifungal, immunomodulatory, cardiovascular protective, anticancer, hepatoprotective, digestive system protective, anti-diabetic, anti-obesity, neuroprotective, and renal protective properties.
To assess the efficacy of Garlic plus Metformin and Garlic has a beneficial effect on blood glucose level, and can be administered to diabetic patients, in the absence of contraindications.

Pages: 44-52  |  153 Views  23 Downloads

How to cite this article:
Amol V Supekar, Bharat V Jadhav, Shital D Sole, Rutuja R Shinde, Akanksha B Sagade and Arti S Satbhai. Synergistic effect of metformin combination with garlic on anti-diabetic activity: A review. Int. J. Pharmacogn. Clin. Res. 2023;5(1):44-52. DOI: 10.33545/2664763X.2023.v5.i1a.32