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International Journal of Pharmacognosy and Clinical Research

Vol. 2, Issue 1, Part A (2020)

Antiplasmodial, inhibitor of hemozoin synthesis and antioxidant activities of some plants used as antimalarial drugs in Bagira (DR Congo)

Author(s):

Bashige Chiribagula valentin, Bakari Amuri Salvius, Okusa Ndjolo, Kahumba Byanga Joh, Duez Pierre, Lumbu Simbi Jean-Baptiste

Abstract:

This study was carried out to evaluate antiplasmodial, inhibitor of hemozoin synthesis and antioxidant activities of 10 plants used in traditional medicine in Bagira in the treatment of malaria. Antiplasmodial activity was carried out by pLDH assay and inhibitory activity of the synthesis of hemozoin, by b-hematin formation assay. The antioxidant activity was evaluated by the DPPH assay. Six plants showed a good activity on W2 strain among them 3 plants showed an inhibitory activity on synthesis of hemozoin and all an antioxidant activity. Dialium angolense, Dalbergia katangensis and Ochna schweinfurthiana showed all tree interest activities with IC50≤ 14.7 ± 0.7 µg / mL. This result establishes a scientific basis for the use of these plants in traditional medicine and highlights a mechanism of action of 3 of them. It prompts the continuation of preferential work to isolate the actives compounds or to develop an improved traditional medicine

Pages: 01-08  |  1179 Views  490 Downloads

How to cite this article:
Bashige Chiribagula valentin, Bakari Amuri Salvius, Okusa Ndjolo, Kahumba Byanga Joh, Duez Pierre, Lumbu Simbi Jean-Baptiste. Antiplasmodial, inhibitor of hemozoin synthesis and antioxidant activities of some plants used as antimalarial drugs in Bagira (DR Congo). Int. J. Pharmacogn. Clin. Res. 2020;2(1):01-08. DOI: 10.33545/2664763X.2020.v2.i1a.13
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International Journal of Pharmacognosy and Clinical Research

International Journal of Pharmacognosy and Clinical Research